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Literature summary extracted from

  • Matassini, C.; Vanni, C.; Goti, A.; Morrone, A.; Marradi, M.; Cardona, F.
    Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors (2018), Org. Biomol. Chem., 16, 8604-8612 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.4 1,4-dideoxy-1,4-imino-D-arabinitol-gold gold glyconanoparticles decorated with the natural iminosugar 1,4-dideoxy-1,4-imino-D-arabinitol, i.e. DAB-1 strongly and selectively inhibit N-acetylgalactosamine-6-sulfatase. The strategy employed allowed the enhancement of the multivalent presentation of the iminosugar onto the surface of gold nanoparticles Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.4 Homo sapiens P34059
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.4 leukocyte
-
 Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.6.4 0.00052
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 1,4-dideoxy-1,4-imino-D-arabinitol-gold